Esomeprazole is used to treat conditions in which there is too much acid in the stomach. It is used to treat duodenal ulcers and gastroesophageal reflux disease (GERD). This is a condition in which the acid in the stomach washes back up into the esophagus. Sometimes esomeprazole is used along with antibiotics to treat ulcers associated with infection caused by the H. pylori bacteria (germ).

Esomeprazole works by decreasing the amount of acid produced by the stomach.